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CNRS
Postdoc position -3D imaging on marine symbioses
France
Europe
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Deadline: Dec 7, 2023

Missions:

The postdoctoral project is part of the SymbiOcean project funded by an ERC consolidator grant, which aims to study plankton photosymbiosis from the ocean at the subcellular, molecular and ecological scales. The main objective of the postdoctoral project is to understand the morphological changes of a symbiotic marine alga by applying 3D cryo-electron microscopy (cryo-TEM), with a particular focus on the strcutral organization of the chloroplast in free-living versus symbiotic stage. The researcher's mission will be to collect and cryofix planktonic symbioses in the ocean during the TREC expedition (https://www.embl.org/about/info/trec/expedition/) for observation using 3D electron microscopy. The researcher will benefit from the team's network of collaborations in Grenoble and within the TREC consortium.

Activities:

Sampling planktonic symbioses in the field - Fluorescence microscopy in cryogenic mode - Image analysis of tomograms (segmentation, 3D reconstruction) from 3D electron microscopy - Communication through international meetings and workshops.

Skills:

- Cell biology or biophysics using electron and/or correlative microscopy. - Knowledge and expertise in sample preparation for 3D electron microscopy (FIB-SEM, cryo-TEM) and fluorescence microscopy in cryo mode. - OR Knowledge and expertise in image analysis for 3D reconstruction after FIB-SEM or cryo-TEM. - Ability to work independently in an interdisciplinary and international environment, and to interact in a young and dynamic research group.

Context:

The researcher will be part of Photosymbiosis team (photosymbiosis.com) of the Cellular and Plant Physiology Physiology Laboratory (UMR 5168 - CNRS -CEA - Univ. Grenoble Alpes - INRAe) in Grenoble. The team's projects aim to better understand the functioning of unicellular photosymbiosis by combining sub-cellular microscopy approaches (nanoSIMS, Synchrotron X-Ray fluorescence, 3D electron microscopy). Locally, the project will work in close collaboration with the IRIG institute: INAC platform (IRIG) and the Institut de Biologie Structurale (IBS, Grenoble). This position is part of an ERC consolidator-funded project (SymbiOCEAN) led by the Photosymbiosis team. Numerous interactions will take place with imaging platforms, and local and international local and international partners during meetings and field sampling.

Baylor University
Electron and Light Microscopy Specialist
Waco, Texas
USA

What We’re Looking For The candidate will mainly be responsible for the operation and maintenance of the Cryo-TEM (including single particle Cryo-TEM, EELS, Micro ED) and will also be involved in the operation and maintenance of the different electron and light microscopes in the Center for Microscopy and Imaging (CMI) at Baylor University. The Electron and Light Microscopy Specialist will train users on the individual microscopes and related techniques. The Electron and Light Microscopy Specialist will assist and support students, faculty and staff with basic and advanced sample preparation of biological and material samples for light and (cryo)-electron microscopy. The specialist will keep records of usage and chemicals in the lab and will also be responsible for waste management, ordering supplies and chemicals.  The CMI at Baylor University facilitates easy-to-use and automated microscopes and equipment for sample preparation for light and electron microscopy. Most equipment in the CMI is covered under a service contract. Visit the following webpage to obtain further information on the instrumentation available at the CMI: http://www.baylor.edu/bsb/cmi

A Master's Degree in Biology, Chemistry, Engineering or related field, up to three years of relevant work experience, and a Christian faith are required. 

A Doctoral Degree in Biology, Chemistry, Engineering or related field, five years of relevant work experience are preferred. 

Preferred experience in light, electron and atomic force microscopy; microscopy facility/laboratory experience and knowledge of sample preparation for light and electron microscopy; experiences in Cryo-EM.

Applicants must be currently authorized to work in the United States on a full-time basis.

What You Will Do

  • Operation and maintenance of the cryo-transmission electron microscope (single particle Cryo-TEM, EELS, Micro ED) and related techniques.
  • Operation and maintenance of the scanning electron, atomic force, and light microscopes.
  • Basic sample preparation of biological samples for transmission electron, scanning electron, and confocal laser scanning microscopy (e.g. fixation, dehydration, embedding in resin, critical point drying, sputter coating, histochemical labeling of proteins, negative staining etc.).
  • Advanced sample preparation of biological samples such as high pressure freezing, plunge freezing, freeze substitution, and Cryo-TEM including sample preparation for single particle analysis.¬†
  • Trimming and sectioning of biological material with Cryo-microtome, Vibratome, Ultramicrotome.
  • Grinding, polishing, and milling (FIB-SEM) of material samples for TEM and SEM.
  • Training of users on the individual microscopes and equipment.
  • Administration of usage records through facility software (FOM).
  • Review and revise technical standard operating procedures and forms.
  • Conduct work in compliance to standard operating procedures and the mission of Baylor University.¬†
  • Ordering chemicals and supplies.
  • Waste management.
  • Perform other related duties as assigned.
  • All duties and responsibilities will be performed under the supervision of the director of the CMI.

What You Can Expect As part of the Baylor family, eligible employees receive a comprehensive benefits package that includes medical, dental, and vision insurance, generous time off, tuition remission, and outstanding automatic retirement contributions. Baylor has a comprehensive benefits plan that supports you and your family’s wellbeing and allows you to be a part of the life of a vibrant and active college campus. To learn more, go to Baylor Benefits & Advantages.

Explore & Engage Learn more about Baylor and our strategic vision, Illuminate. Also, explore our great hometown of Waco and the many opportunities to engage locally. If you are new to Central Texas, This is Waco!

Yale School of Medicine
Senior Staff Scientist
New Haven, Connecticut
USA

Position Focus: Senior Staff Scientist position available in the FIB-SEM Collaboration Core (F-SCC) (https://medicine.yale.edu/fib-sem/) of Yale School of Medicine. At the forefront of volume Electron Microscopy, the F-SCC utilizes the state of the art enhanced Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) technology for large volume imaging with nanometer isotropic resolution. Under supervision of the Director of F-SCC, the candidate will play a leadership role in managing electron microscopy (EM) sample preparation lab within F-SCC. Explicitly, the candidate will be responsible for optimizing the existing electron microscopy (EM) sample preparation protocols of biological specimens and developing new methods for clinical specimens. The candidate is expected to perform independent research, experiments, and laboratory techniques, and work closely with supervisor, internal and external collaborators, and group members. Responsible for the daily operation of EM sample preparation lab within F-SCC, and related data analysis for research projects. While the job duty will evolve according to the needs of the organization, specific responsibilities include:

  1. Carry out work requests using EM sample preparation methods with heavy metal staining and resin embedding, followed by transmission electron microscopy (TEM) imaging to evaluate sample quality. Perform transcardial perfusion on animal as needed.
  2. Optimize the existing electron microscopy (EM) sample preparation protocols of biological specimens.
  3. Develop new protocols for clinical specimens.
  4. Develop automated EM sample preparation pipeline.
  5. Participate in FIB-SEM sample preparation including sample mounting, trimming, and targeting to specific region of interest using ultramicrotome guided by x-ray micro-CT.
  6. Explore and develop new methods to support the advances in volume electron microscopy.

Dept/Section URL Click here for more information 

Essential Duties 1. Carries out the wide range of specialized scientific methods and procedures used in the laboratory. 2. Responsible for resource planning, allocation, and planning renovations. Determines, develops, and implements the operative framework of the laboratory as it relates to long-term goals, needs, and direction. 3. Keeps abreast of newly-evolving technologies, instrumentation, and methodologies and purchases new instrumentation. 4. Develops, analyzes, interprets, and summarizes scientific results. 5. Establishes policies and procedures governing operation of the laboratory. 6. Independently investigates and solves biotechnological problems as they arise through research and extensive literary searches. Determines subsequent experimental approaches. 7. Independently decides when additional analyses are needed, arranges for the needed analyses and interprets the resulting design and implements customized protocols. 8. Authorizes and organizes the use of laboratory and equipment to ensure timely completion of research projects. 9. May perform other duties as assigned.

Required Education and Experience Master’s Degree in chemistry, biology, biochemistry, or other related discipline and five years of experience or an equivalent combination of experience and education Required Skill/Ability 1: Proven ability to develop new EM sample preparation protocols and to automate EM sample preparation pipeline to support the advances in volume electron microscopy. Required Skill/Ability 2: Proven ability to operate instrument and modify its design for improved performance and troubleshoot associated issues. Required Skill/Ability 3: Proven ability to search and interpret scientific papers, protocols, standard operating procedures, safety standards, maintenance instructions and procedure manuals for laboratory equipment. Required Skill/Ability 4: Demonstrated capability to manage laboratory facilities and workspaces. Proven ability to plan project needs to optimize resources necessary for successful project completion. Required Skill/Ability 5: Proven ability to participate in writing of grant proposals and manuscripts.

Preferred Education, Experience and Skills: Ph.D. degree in biology, chemistry, engineering, or other related disciplines plus seven or more years of relevant experience. Special considerations will be given to candidates who have strong background in EM sample preparation and EM protocol development and have strong interest in automation.

EMBL
Scientific Project Manager - foundingGIDE at the Euro-BioImaging Bio-Hub, EMBL, Heidelberg
Heidelberg, Germany
Europe
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Deadline: Dec 8, 2023

The Euro-BioImaging Bio-Hub team at EMBL Heidelberg is looking for a highly motivated Scientific Project Manager to support the operation of the newly funded EU project, foundingGIDE. The project will lay the foundation for a Global Image Data Ecosystem (GIDE) that connects different biological and biomedical image data resources across the globe to allow metadata and data sharing, establishing image data as a Findable, Accessible, Interoperable and Reusable resource for the global scientific community. Please help us find a team member to drive the engagement with the international research community and contribute to this ground-breaking project through the organization of workshops and hackathons, scientific dissemination, and engagement with international imaging initiatives. 

EMBL
Scientific Project Manager for User Management & Staff Training, Euro-BioImaging Bio-Hub, EMBL, Heidelberg
Heidelberg, Germany
Europe
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Deadline: Dec 8, 2023

The Euro-BioImaging Bio-Hub team, located at EMBL Heidelberg, is looking for a Scientific Project Manager for User Management & Staff Training. This colleague will support researchers accessing Euro-BioImaging services, engage new user groups, and will contribute to developing & organizing training for core facility staff. Wide knowledge of imaging techniques, familiarity with what it’s like to work in a core facility, and interest in community building and outreach will be keys to success in this exciting position.

Institute of Molecular Pathology
Postdoctoral Researcher on Instrumentation for Single Molecule Studies
Vienna, Austria
Europe
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Deadline: Dec 1, 2023

The research group of Francisco Balzarotti at the Research Institute for Molecular Pathology (IMP) offers a position for a highly motivated Postdoctoral Researcher, who is interested in the fields of super reso­lution microscopy and single molecule tracking. Our Group. We develop novel optical methods and instrumentation for the observation of biological phenomena with the highest fidelity. We focus on schemes that require outstanding performance in terms of spa­tial and/or temporal resolution, such as super resolution fluorescence imaging and single-molecule tracking. By bringing together expertise in optics, labelling and photophysics, we develop solutions to transverse obstacles in biology and biophysics within a highly collaborative envi­ronment. The Projects. The advent of Super Resolution Microscopy has un­locked the access to spatial resolutions beyond the diffraction limit of visible light (~250nm), becoming an invaluable tool for exploring the structure and function of biological processes. The recently introduced MINFLUX concept has pushed even further the possibilities of molecu­lar localization in terms of spatio-temporal resolution. Driven by these concepts, the successful candidates will develop instrumentation to fill current technological gaps, while answering concrete biological ques­tions in association with the rich and collaborative environment of the Vienna BioCenter. The Candidates. The candidates should be curious, creative and excited about learning new topics and skills! Despite the emphasis on technology development within our group, a candidate with experience/knowledge/interest in biol­ogy will make a great match. This is the driving force of our environment at the Vienna BioCenter, where there is extensive exposure to diverse topics in biology. Successful candidates should hold a PhD degree in the fields of physics or engineer­ing. Additionally, the following aspects are desirable:

  • Theoretical and hands-on experience in optics and microscopy
  • Experience in the field of super resolution microscopy
  • Programming proficiency in Py¬≠thon, MATLAB, LabView, FPGA and/or GPU
  • Experience with electronics (circuitry, microcontrollers, high frequency/high voltage)
  • Experience in statistics, stochastic processes and control theory
  • Experience in photophysics of dyes and fluorescent proteins Our Environment.¬†The¬†Research Institute of Molecular Pathology (IMP)¬†in Vienna is a basic biomedical research institute largely spon¬≠sored by Boehringer Ingelheim. With over 200 scientists from 40 coun¬≠tries, the IMP is committed to scientific discovery of fundamental mo¬≠lecular and cellular mechanisms underlying complex biological phe¬≠nomena. The IMP is located at the Vienna BioCenter, one of Europe‚Äôs most dynamic life science hubs with 1,800 employees from 70 countries in four research institutes, three universities and two dozen biotech companies. Application.¬†Interested candidates should send their application (motivation letter,¬†CV,¬†contact details for references) directly by email to¬†francisco.balzarotti[at]imp.ac.at.
Chan Zuckerberg Imaging Institute
Software Engineer - Machine Learning for CryoET
Redwood City, California
USA

The Chan Zuckerberg Imaging Institute is seeking an experienced Software Engineer - Machine Learning for CryoET, to work under a technology team leader and collaborate in developing software that supports the evaluation and analysis of CryoET data. Will work closely with researchers, scientists, and engineers to develop novel approaches in cryoEM.

  • Implement, extend, and develop ML models for cryoET
  • Work with Python, ML frameworks, napari
  • Assist in the design of machine learning challenges related to CryoET
Centre of Light for Life, University of Adelaide
ARC Grant-Funded Researcher B- Imaging
Adelaide, South Australia, Australia
Australia and Oceania
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Deadline: Dec 3, 2023

The University of Adelaide is seeking applications for 1 x ARC Grant-Funded Researcher for a 2-year fixed term appointment to commence as soon as possible. The specific topic area of these posts is the development of new light-based imaging technologies and their translation to biological research or industry. The successful applicants will play leading roles in developing and implementing classical and quantum concepts for imaging within a vibrant team. The work is based within the new Centre of Light for Life. The centre aims to build upon the area of photonics and its applications in other multidisciplinary fields. The imaging will be conducted with a range of biological samples, including mouse embryos and other reproductive cells, zebrafish, other marine mammals, and human tissue. The project will use novel photonics and address challenges including those in infertility, neurodegenerative disease. The successful applicants will be required to undertake both experimental work and numerical studies and will be expected to liaise with key institutes such as the Institute of Photonics and Advanced Sensing and biologists in the Faculty of Health & Medical Sciences. (Level B) $107,276- $126,894 per annum plus an employer contribution of 17% superannuation

University of Knoxville, Tennessee
Postdoctoral Research Associate in Experimental Biophysics
Knoxville, Tennessee
USA

A position is open in the Mannik Lab for a highly motivated Postdoctoral Researcher who has a doctorate in biophysics, cell biology, or a related field who is interested in energy-driven self-assembly processes in living systems. The processes of interest include the dynamic assembly of cell division machinery and cell cycle control in E. coli. The position involves high-resolution and high-throughput microscopy, computational data analysis (including AI models), microfluidics, and bacterial cell biology. The person can also contribute to our efforts to develop nano/microfabricated fluidic devices for live cell studies, with fabrication taking place at the nearby Oak Ridge National Laboratory. This work is supported by funding from the National Institutes of Health (NIH) and the National Science Foundation (NSF). For more details about potential projects, please visit: https://volweb.utk.edu/~jmannik/index.html

The applicants should send a CV, a cover letter describing research interests/relevant experience, and names of three references to Dr. Jaan Männik at JMannik@utk.edu.

The University of Tennessee, Knoxville, is in a naturally beautiful area near the Smokey Mountains National Park and the Big South Fork National Recreation Area. Knoxville also has a vibrant literary, arts, and music scene, a lively downtown, and affordable living.

Fondazione Human Technopole
Postdoc in Artificial Intelligence
Milan
Europe
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Deadline: Dec 20, 2023

Are you an AI expert with a passion for the life sciences? We invite you to become part of the Jug Lab, a dynamic and interdisciplinary research team situated at the prestigious Human Technopole (HT) in Milan, Italy. 

The Jug Lab is conducting frontier research, combining Computer Vision and Machine Learning to further cutting-edge projects with applications in the life sciences.  We devise novel methods that enable or simplify life science research. 

Come and explore new frontiers in spatial ‚Äėomics and multi-modal analyses!¬†Such efforts can easily be conducted in collaboration with other Research Centres at Human Technopole! The promise: full support, so your postdoctoral experience can be as fruitful as possible!

The link will bring you to a page containing more details... click it! :)

The Morgridge Institute for Research
Assistant Systems Programmer
Madison, Wisconsin
USA
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Deadline: Dec 31, 2023

As an independent research organization, the Morgridge Institute for Research explores uncharted scientific territory to discover tomorrow’s cures. In affiliation with the University of Wisconsin-Madison, we support researchers who take a fearless approach to advancing human health in emerging fields such as regenerative biology, metabolism, virology and biomedical imaging. Through public programming, we work to inspire scientific curiosity in everyday life.

Job Purpose:

The Morgridge Institute for Research seeks an Assistant Systems Programmer to support research projects and day-to-day operations of the Skala Lab. The Skala lab collaborates with UW-Madison Biomedical Engineering to develop new methods to understand and combat cancer using photonics-based technologies, and is particularly interested in developing personalized cancer treatment strategies and more effective cancer therapies. The Assistant Systems Programmer will be responsible for independently conducting imaging experiments, performing quantitative image analysis, and undertaking machine learning projects. She or he will complete all work while following biosafety, animal, and human subjects research regulations and guidelines.

Primary Responsibilities:

  • Perform imaging experiments and quantitative image analysis.
  • Investigate relevant image analysis technologies that may improve research.
  • Develop cell segmentation processes.
  • Undertake projects requiring machine learning techniques.
  • Keep up to date with training per safety and protocol requirements.
  • Clearly communicate research progress results to project stakeholders
  • Prepare weekly overviews of work completed and planned. Give updates, including outlining progress and setbacks, and solicit feedback in regular meetings.
  • Contribute ideas and feedback to other researcher‚Äôs projects in regular meetings.
  • Utilize expertise to assist or lead other projects within the laboratory as appropriate.
  • Form and contribute to collaborations with other labs. Maintain relationships with collaborators and hold oneself to professional standards.
  • Other miscellaneous duties as required.

    Requirements

    To perform this job successfully, an individual must be able to perform each primary duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the primary duties.

    Education and Experience

  • Minimum bachelor‚Äôs degree in biomedical engineering, computer science, physics, biology, or related discipline.
  • Experience in programming, e.g. Python, micromanager, C, C++, Matlab, Labview, R.
  • Experience in machine learning.
  • Experience with laboratory research, microscopy, and image analysis is preferred.

    Knowledge, Skills and Abilities Required

  • Experience in programming, e.g. MatLab, Python, R, micromanager, C, C++, Labview.
  • Strong background in biology and computer science or engineering.
  • Ability to perform reproducible quantitative imaging experiments.
  • Working knowledge of quantitative analysis.
  • Ability to leverage previous experiences to learn and develop new skills.
  • Ability to take initiative and independently evaluate project options.
  • Ability to handle multiple assignments concurrently while working independently and effectively under deadlines.
  • Ability to work both independently and as part of a dynamic research team.
  • Excellent attention to detail.
  • Strong written and oral communication skills.
  • Strong organization skills and attention to detail.

In order to insure the safety of our workplace, proof of COVID-19 vaccination is required unless an exemption is granted for medical, disability or religious reasons.

Qualified individuals interested in this opportunity are required to submit a cover letter and resume via the link below

Chan Zuckerberg Imaging Institute
Engineer I - Electron Microscopy Technology Platform
Redwood City, California
USA

The Opportunity

The Chan Zuckerberg Imaging Institute is seeking an experienced¬†Engineer I ‚Äď Electron Microscopy Technology Platform¬†to be responsible for specimen preparation, FIB milling, cryoET data collection, and user support. The facility supports a wide range of cutting-edge imaging and analysis needs for leading researchers and technology developers at the CZ Imaging Institute. This role will support world-class scientists to tackle the most challenging imaging problems.

What You'll Do

  • Run electron microscopy instruments including the FIB milling and Krios
  • Prepare samples using plunge freezing and high pressure freezing
  • Collect cryo-electron tomography data
  • Assist with equipment maintenance and operation in accordance with manufacturer's recommendations and safety guidelines
  • Support with ordering supplies
  • Stay current with new technologies and developments in the field of electron microscopy

    What You'll Bring

    Essential - 

  • Bachelors degree in science
  • At least 3 years experience in electron microscopy
  • At least 1 year experience in cryo milling on FIB/SEM
  • Excellent communication and interpersonal skills
  • Strong organizational and problem-solving skills
  • Ability to work independently and as part of a team Nice to have -
  • Krios microscope and cryotomography experience The Chan Zuckerberg Biohub Network¬†requires all employees, contractors, and interns, regardless of work location or type of role, to provide proof of full COVID-19 vaccination, including a booster vaccine dose, if eligible, by their start date. Those who are unable to get vaccinated or obtain a booster dose because of a disability, or who choose not to be vaccinated due to a sincerely held religious belief, practice, or observance must have an approved exception prior to their start date.
Chan Zuckerberg Imaging Institute
Lab Manager - Wet Lab Platform
Redwood City, California
USA

The Opportunity The Chan Zuckerberg Imaging Institute is seeking an experienced Lab Manager - Wet Lab Platform to lead build out of our wet lab infrastructure in our new imaging facility in Redwood Shores, Ca. Will work closely with researchers and scientists developing novel approaches in cryoEM. What You'll Do

  • Responsible for general wet lab, safety, and scientific facility management
  • Implementation of biological and chemical safety protocols (in cooperation with EH&S consultant)
  • General oversight of scientific instruments and usage management
  • Tracking and handling service contracts of scientific instruments and equipment
  • Opportunity to participate in biological research projects
  • Plan, coordinate, and execute laboratory & research activities, ensuring training and adherence to protocols, safety guidelines, and regulatory standards
  • Manage inventory of laboratory supplies, equipment, and reagents, and ensure their proper maintenance and calibration
  • Maintain a safe working environment, addressing potential hazards and promoting a culture of laboratory safety
  • Experience with mammalian cell cultures (and potentially IPSCs) and/or CRISPR What You'll Bring Essential¬†-¬†
  • BS degree in biological science or a related field
  • At least 5 years of research and/or lab management experience
  • Excellent problem solving skills
  • Excellent communication skills
  • An open and collaborative mindset Nice to have -¬†
  • A passion for developing and maintaining a high quality, state-of-the-art laboratory environment
  • A teaching mentality and experience mentoring others
  • Experience working in an startup environment
  • An interest in science and learning about biological imaging
  • Experience operating complex scientific instruments (such as light or electron microscopes)

The Chan Zuckerberg Biohub Network requires all employees, contractors, and interns, regardless of work location or type of role, to provide proof of full COVID-19 vaccination, including a booster vaccine dose, if eligible, by their start date. Those who are unable to get vaccinated or obtain a booster dose because of a disability, or who choose not to be vaccinated due to a sincerely held religious belief, practice, or observance must have an approved exception prior to their start date.

Chan Zuckerberg Imaging Institute
Research Associate - Wet Lab Platform
Redwood City, California
USA

The Opportunity

The Chan Zuckerberg Imaging Institute is seeking an experienced Research Associate - Wet Lab Platform, to support the Wet Lab Manager and build out our wet lab infrastructure in our new imaging facility in Redwood Shores, Ca. Will work closely with researchers and scientists developing novel approaches in cryoEM.

What You'll Do

  • Perform general biological wet lab duties including: preparing buffers and media, checking supplies, maintaining glasswash
  • Assist with the establishment and maintaining of mammalian cell cultures
  • Assist researchers in setting up, conducting, and monitoring molecular and cell biological experiments according to established protocols
  • Operate and maintain a variety of laboratory instruments, such as microscopes, centrifuges, pipettes, and spectrophotometers

    What You'll Bring

    Essential - 

  • BS degree in biological science or a related field
  • One to two years of hands on wet laboratory experience
  • Excellent problem solving skills
  • Excellent communication skills
  • An open and collaborative mindset Nice to have -¬†
  • A passion for developing and maintaining a high quality, state-of-the-art laboratory space
  • Experience working in an startup environment
  • An profound interest in science and learning about biological imaging
  • Experience using complex scientific instruments (such as light or electron microscopes) The Chan Zuckerberg Biohub Network¬†requires all employees, contractors, and interns, regardless of work location or type of role, to provide proof of full COVID-19 vaccination, including a booster vaccine dose, if eligible, by their start date. Those who are unable to get vaccinated or obtain a booster dose because of a disability, or who choose not to be vaccinated due to a sincerely held religious belief, practice, or observance must have an approved exception prior to their start date.
Chan Zuckerberg Imaging Institute
Senior Engineer - Electron Microscopy Technology Platform
Redwood City, California
USA

The Opportunity

The Chan Zuckerberg Imaging Institute is seeking an experienced  Senior Engineer - EM Technology Platform to be responsible for the overall operation and management of the facility, including implementing innovative hardware and software solutions, equipment maintenance, staff supervision, and user support. The facility supports a wide range of cutting-edge imaging and analysis needs for leading researchers and technology developers at the CZ Imaging Institute. This role will collaborate closely with world-class scientists to tackle the most challenging imaging problems.

What You'll Do

  • Manage a suite of instruments including transmission electron microscopes, focus ion beam scanning electron microscopes, cryo light microscopes, high pressure freezers, etc.
  • Supervise and manage the facility staff, including hiring, training, and performance evaluations Ensure that all equipment is maintained and operated in accordance with manufacturer's recommendations and safety guidelines
  • Develop and implement policies and procedures for the use of the facility
  • Coordinate with researchers and technology developers to understand their imaging needs and develop solutions to meet those needs
  • Develop and maintain relationships with vendors and suppliers of equipment and supplies
  • Ensure that equipment and supplies are ordered and received in a timely manner
  • Stay current with new technologies and developments in the field of electron microscopy and integrate these into the workflows at the facility
  • Collaborate with other facility managers and support staff to ensure that the facility is integrated with the Institute's overall research operations

    What You'll Bring

    Essential - 

  • PhD in structural biology or a related field
  • At least 5 years relevant experience
  • At least 3 years of experience managing an electron microscopy facility or related research facility
  • Strong knowledge of electron microscopy fundamentals, techniques, and equipment, including
  • Proficiency preparing specimens using FIB milling
  • Deep understanding of cryo electron tomography
  • Strong leadership and management skills
  • Excellent communication and interpersonal skills
  • Strong organizational and problem-solving skills
  • Ability to work independently and as part of a team The Chan Zuckerberg Biohub Network¬†requires all employees, contractors, and interns, regardless of work location or type of role, to provide proof of full COVID-19 vaccination, including a booster vaccine dose, if eligible, by their start date. Those who are unable to get vaccinated or obtain a booster dose because of a disability, or who choose not to be vaccinated due to a sincerely held religious belief, practice, or observance must have an approved exception prior to their start date.
Chan Zuckerberg Imaging Institute
Software Engineer - Data Integration
Redwood City, California
USA

The Opportunity

The Chan Zuckerberg Imaging Institute is seeking an experienced Software Engineer - Data Integration to work under a technology team leader and collaborate in developing software that supports interfaces for high-end microscopic instruments. Will work closely with researchers, scientists, and engineers developing novel approaches in cryoEM.

What You'll Do

  • Write software to support interfaces to high-end instruments
  • Develop automated workflows for data acquisition and analysis across multiple modalities (Transmission and Scanning Electron Microscopy, Light Microscopy)
  • Integrate software with databases for tracking all data and metadata across modalities
  • Develop a user interface to the workflow

    What You'll Bring

    Essential - 

  • MS in Computer Science or a comparable/relevant degree
  • At least 2 years of relevant experience preferably in lab automation and interfacing software with scientific instruments
  • Experience working with the Python language
  • Well developed analytical observation and software optimization skills combined with interest to understand the scientific impact of software performance
  • Deep understanding of software engineering principles and design patterns and how to apply them
  • Excellent problem solving skills
  • Excellent communication skills
  • An open and collaborative mindset
  • A passion for developing high quality, robust software Nice to have -
  • Experience in experimental physics, robotics or computer science
  • A teaching mentality and experience mentoring others
  • An interest in science and learning about biological imaging
  • Experience working in an startup environment
  • Diverse experience working with both desktop and web applications and understanding how they can interface with each other
  • Hands-on experience interfacing with scientific hardware such as microscopes
  • Experience working with cloud services like AWS
  • Experience working with mysql and/or javascript The Chan Zuckerberg Biohub Network¬†requires all employees, contractors, and interns, regardless of work location or type of role, to provide proof of full COVID-19 vaccination, including a booster vaccine dose, if eligible, by their start date. Those who are unable to get vaccinated or obtain a booster dose because of a disability, or who choose not to be vaccinated due to a sincerely held religious belief, practice, or observance must have an approved exception prior to their start date.
Arcadia Science
Scientist, Image Analysis
Berkeley, California
USA

A Bit About Us: We are Arcadia Science. Arcadia is a science company founded and led by scientists. Our mission is to transform evolutionary innovations into real-world solutions by openly developing more efficient, replicable, and sustainable ways to leverage the biology of diverse organisms.

The Opportunity:

We are seeking a highly collaborative and motivated scientist who is excited about statistical analysis of microscopy data and generating computational tools for biologists. With this hire, we plan to expand functionality in high-content image analysis and expand the predictive capacity of novel features from multi-modal data types. We are looking for someone who enjoys working in a team environment and responds well to the fast pace and iterative nature of experimental work. Enthusiasm for open science is required as we publish our work in smaller units, quickly, and iteratively. 

The overarching goal of the Microscopy Team’s efforts at Arcadia is to enable discovery across the tree of life using label-free image-based experimental approaches. As a part of Arcadia’s Discovery Platform, we are pursuing tools and approaches that are highly adaptable and scalable as we build capacity for high-content imaging experiments across a wide range of organisms. Our Team aims to iterate on existing tools and build flexible pipelines for image processing and statistical analysis that will be deployed for different experimental needs, whether that is through collaboration with scientists at Arcadia or shared openly in the broader community. 

We believe there is untapped potential to extract quantitative information from data-rich videos of live organisms moving in 3D over time. Whether we are working with datasets generated in-house or from open-source data, our goal is to be able to input largely label-free images (DIC/Phase/autofluorescence), quickly get a sense of the distribution of data on many features in the image, and robustly test hypotheses through statistical analysis. 

Within 3 months, you should be able to develop computational pipelines that input raw microscopy data and process the data appropriately, extract quantitative metrics, and statistically evaluate the signal. You should feel ready to implement specific statistical analyses to evaluate the composition of high-resolution images in terms of fine features, volumes of specific shapes and sizes, and identify other signatures without a priori knowledge. You should be able to implement comparative analyses of the morphology and motility of cells/organisms from video data. 

Within the first 6 months, you may also enable new imaging approaches by combining computational algorithms with collecting different types of microscopy data. You may employ machine-learning models to analyze imaging data in high-throughput ways. Throughout this time, you will be solving analysis problems for different projects and collaboratively writing short publications on this work.

If you are a curious person with programming and analytical skills that sound complementary to these types of data, and have a strong background in statistical analysis, please review the responsibilities and answer the questions below. 

Responsibilities

- Designing and implementing computational pipelines for processing of biological data from microscopy images
- Applying appropriate statistical analysis methods for biological data 
- Processing and analyzing high-content microscopy images especially those that are label-free and high-throughput
- Collaborating with biologists and integrate user-feedback into the processing/analysis pipelines
- Communicating readily at different levels of technical expertise
- Applying statistical rigor to a variety of data
- Helping to design figures and write pubs

Education/Experience (Required)

- PhD in Computational Biology, Bioinformatics, Applied Math, Biology, Biomedical Engineering or a related field.
- Experience in image processing and scientific programming in Python (e.g. NumPy, SciPy, scikit-image, PyTorch, etc) and/or R, or MATLAB.
- A strong background in statistical analysis, ideally with biological data (e.g. multivariate models, waveform analysis, Fast Fourier Transform and spectral analysis, denoising and deconvolution algorithms).

Education/Experience (Preferred)

- A strong background in image processing including segmentation, object identification, quantification, and feature extraction.
- Experience in computational imaging and image reconstruction algorithms (e.g. quantitative phase, Fourier ptychography). 
- Experience with fluorescence microscopy, brightfield microscopy, DIC, phase, or other.
- Experience with video data as well as 3D stacks of images. 
- Experience building, maintaining, and using large-scale datasets.
- Excellent interpersonal and project management skills.
- Excellent written and oral communication skills.

Successful applicants can expect to be compensated between 125-150K with benefits and a highly competitive equity offering, depending on experience level. The scientist is part of the microscopy team, and reports to Tara Essock-Burns. The position will require the individual to be on-site at our Berkeley, California headquarters.

Application Process: Interested applicants should send a resume and a one-page cover letter that addresses their interest and qualifications for the position.

Arcadia Science is an equal opportunity workplace; we welcome people from all backgrounds and communities. We provide competitive compensation and practical benefits to keep you happy and healthy so that you can do your best work.

Please note that an offer of employment from Arcadia is contingent upon the successful clearance of a reference and background check.

Allen Institute for Brain Science
Scientist I - Machine Automation - Whole Mouse Brain - Sample Preparation
Seattle, Washington
USA

Not specifically a microscopy job, but microscopy adjacent; this position is to support our volume EM efforts in neuroscience. Please refer all interested people to apply at the URL listed.

https://alleninstitute.org/careers/?p=2&jobId=45da560f-39ac-5d51-dbc0-52a1f26f4b4f#actively-seeking-passionate-people-6

Scientist I ‚Äď Whole Brain Electron Microscopy - Imaging The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling and theory. We are seeking a scientist to work on developing novel large scale Electron Microscopy (EM) approaches. The scientist will be responsible for scaling and automating the EM imaging of whole mouse brain sections across a mouse hemisphere. This will involve modifying Transmission Electron Microscopes (TEMs) to handle large sections (~ 1 cm2) and testing tomographic strategies. The goal of the research is to create the technologies to allow the complete mapping of synaptic connectivity of individual neurons across the entire mouse brain, something that has never been done before. The project will first apply this technology within the Cortico-Thalamic-Basal-Ganglia loop to discover cell types and test models of neural computations within this circuit. The scientist will be an essential member of the EM connectomics project studying cell types and will also have opportunities for data analysis in later phases of the project. We are a dynamic multi-disciplinary team with deep expertise in electron microscopy and contribute to cutting-edge research in the field! Our team has already cut and imaged multiple datasets with tens of thousands of sections, making it an exciting time to join and achieve the next level of impact and scaling. No previous sectioning experience is required, as we welcome enthusiastic applicants who are new to the field but possess a strong interest in automation and a passion for scientific progress. The team already includes several EM experts, and therefore also welcomes applicants that are new to electron microscopy but have a strong interest in automation and in the overall goals of the project. Examples of work related to this position can be found on: https://www.nature.com/articles/s41467-020-18659-3 https://elifesciences.org/articles/76534 https://www.cell.com/cell/pdf/S0092-8674(22)00134-9.pdf https://www.pnas.org/doi/10.1073/pnas.2202580119 https://www.biorxiv.org/content/10.1101/2021.07.28.454025v1 https://www.biorxiv.org/content/10.1101/2023.01.23.525290v1 The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

University of Toronto
Postdoc in Single-Molecule Imaging of Embryonic Development
Toronto, Ontario
Canada

A postdoctoral position at the University of Toronto is immediately available for exceptional candidates interested in applying single-molecule imaging to study the molecular and cellular mechanisms involved in the development of the fruit fly embryo. The position will be under the joint supervision of Dr. J. N. Milstein in the Department of Physics (https://www.utm.utoronto.ca/milsteinlab/) and Dr. R. Fernandez-Gonzalez at the Institute of Biomedical Engineering (https://www.quantmorph.ca/)

Qualifications:

  • A keen interest in interdisciplinary research.
  • Ph.D. in Physics, Chemistry/Biochemistry, Biomedical Engineering, Quantitative Biology, or related field.
  • A track record of scientific productivity.
  • Have strong verbal and written communication skills.
  • The position is funded for a two-year period with an initial salary of $50k/year + benefits. Applicants should directly contact Dr. J. Milstein by email (josh.milstein@utoronto.ca). In your correspondence, please provide an up-to-date CV and contact information for three references.

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ2S+ persons, and others who may contribute to the further diversification of ideas.

University of Texas at Austin, Center for Biomedical Research Support
Deputy Executive Director
Austin, Texas
USA

The Center for Biomedical Research Support (CBRS) is a collection of 10 service centers that operates under the Vice President for Research, Scholarship and Creative Endeavors and broadly supports the research community on campus and externally. CBRS serves a central role across all of campus to provide access to cutting-edge technology, expert advice, and centralized services. CBRS is comprised of core facilities including Biomedical Imaging, Bioinformatics, Biological Mass Spectrometry, Biomedical Research Computing, Cryo-EM imaging, Genome Sequencing, Microscopy/Flow Cytometry and Mouse Genetic Engineering. In addition, CBRS provides laboratory support in the forms of stockrooms, electronics repair, and external services drop boxes. The Deputy Executive Director serves the role of unifying operations and serving as a leader within CBRS as well as a connection to external offices and units outside of CBRS.

University of Minnesota U54 Center for Multiparametric Imaging of Tumor Immune Microenvironments
Researcher 5
Minneapolis, Minnesota
USA

"Qualifications Required: A Ph.D. in a relevant field of Engineering or Biology or a related field and a demonstrated track record of productive research is required (1st author publications in established societal or field-leading journals).   Preferred: Candidates should be experienced in optical imaging. Experience with essential techniques of cell biology and multiphoton microscopy is desirable. Successful candidates will be able to independently design imaging experiments and analyze molecular to cell scale imaging data. Successful candidates will also have excellent communication and organizational skills, creative approaches to experimental design, and must be able to work collaboratively.     Principal Duties and Responsibilities: We have an opening for a research scientist (funded by multiple societal and NIH grants, including the University of Minnesota U54 Center for Multiparametric Imaging of Tumor Immune Microenvironments), available immediately in the Department of Biomedical Engineering and the Masonic Cancer Center at the University of Minnesota-Twin Cities. The objective of this team science work is perform advanced imaging experiments of archival samples (e.g. histology and immunohistochemistry or immunofluorescence slides) and live cells and tissues. The work will not fully center around a single project or grant, but a broader imaging base to support multiple projects and emerging collaborations. The successful candidate will use advanced optical imaging, primarily multiphoton excitation, second harmonic generation, and multiphoton fluorescence lifetime imaging microscopy, as well as more standard linear microscopies (such as confocal microscopy), to advance our understanding of cancer cell behaviors dynamics, particularly dynamics of key immune cell populations in solid tumors. The candidate will be responsible interacting and integrating with teams of graduate students, postdoctoral trainees, and research scientists in the Provenzano lab. The candidate will also be responsible for interfacing with collaborating laboratories and coordinating experiments. The candidate will also be responsible for analyzing data, helping preparae of manuscripts along with the PI, and presenting results to the PI and at local, regional, and national meetings.  

  • Work in conjunction with faculty mentor who determines the research agenda. (5%)
  • Design and carry out experiments and analyze data (75%)
  • Prepare and present data to study investigators. (10%)
  • Author, co-author, and otherwise collaborate on reports, conference papers and journal articles. (10%)"

"How to Apply: Applications must be submitted online: https://humanresources.umn.edu/content/find-job (Job Opening ID 348078). To be considered for the position, please click the ‚ÄėApply‚Äô button and follow the instructions. You will have the opportunity to complete an online application for the position and attach a cover letter and resume."

The University of California: San Francisco
Biological Imaging CoLab Director
San Francisco , California
USA
Learn More
Deadline: Jan 21, 2025

We are recruiting a new director for the Biological Imaging Development CoLab (BIDC) at the University of California in San Francisco.

CoLabs (http://colabs.ucsf.edu/) is a new model for supporting collaborative research at UCSF. The BIDC is one of five CoLabs teams with specialized research and technical expertise in analyzing biological samples using various approaches. These teams work together closely and collaborate with a large group of investigators in many UCSF departments. BIDC’s missions include microscopy education, training, consulting, and technical support and microscopy research and development.

The BIDC Director role is multifaceted and requires independence, initiative, organization, and flexibility. The incumbent must have experience in biological-related microscopy research, strong interpersonal skills to work closely with investigators, students, postdoctoral fellows, visiting scholars, and staff members, and strong time management skills. The incumbent also must have strong mentoring and leadership skills.

In general, the BIDC Director’s activities will include, but are not limited to: maintenance and management of the Biological Imaging Development CoLab’s (BIDC) microscopes and support equipment; training and assisting new users on microscopes, techniques, and data analysis; assisting in experimental design and analysis pipelines; direct supervision of two or more employees; oversight of CoLab’s budget including salaries and materials; coordinating team members for new initiatives and projects; and the mentoring and career development of co-workers. The BIDC Director is also responsible for keeping the facility current with trends and needs of the microscopy community. This is accomplished either through the raising funds and purchasing commercial equipment, designing and developing technology, or adding new support resources for the research community. The incumbent will report directly to the Director of the CoLabs and the BIDC Steering Committee.

Required qualifications:

A PhD in natural sciences; biology, chemistry, physics, or related discipline. At least 5 years of experience in microscopy-based instrument development. At least 5 years of experience in high-dimensional microscopy data analysis. At least 5 years of experience in biology specific microscopy techniques and analysis. Proficiency in microscopy data analysis using available software such as Imaris, Elements, LAS, FIJI, ImageJ, and Ilastik. Demonstrated skills and experience in teaching and mentoring graduate students and professional trainees. Strong interpersonal skills and the ability to work with individuals from diverse backgrounds. Strong time management skills and demonstrated attention to details. Preferred qualifications:

Excellent written and verbal communication including writing of research manuscripts, and scientific oral presentations (in-person and virtually). Experience in preparing grant proposals, especially shared equipment grant proposals. Experience in management of a shared research resource or core facility. Proficiency in custom microscopy data analysis using Matlab and Python. Hands-on experience in confocal, widefield, light-sheet, and super-resolution microscopy techniques. Experience in computer assisted drawing (CAD) for instrument design and development. Experience in electrical circuit design with soldering skills.

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