Job Openings

Senior Postdoctoral Position in Single Molecule Microscopy Department of Molecular Immunology at the University of Freiburg (Germany) (https://lillemeier.biologie.uni-freiburg.de)   We are seeking a highly creative, collaborative, and motivated Senior Postdoctoral Researcher with significant experience in single molecule microscopy who is interested in visualizing immune responses in T cells.   This full-time senior postdoctoral position is available from 1st of January 2026 with the possibility of becoming permanent after 2 years. The salary is at E13 level by the TV-L agreement (Tarifvertrag für den öffentlichen Dienst der Länder / collective agreement for public employers). We welcome applicants from different areas, e.g. immunology, biology, physics and engineering, with considerable expertise in fluorescence single molecule microscopy using state-of-the-art equipment and a keen interest in immunology. The candidate is expected to conduct studies independently and supervise postdoctoral researchers and students on microscopy projects. This position requires a Ph.D. degree (or equivalent), and publications in peer-reviewed journals. We are an equal opportunity employer and encourage applications from candidates of all genders.  

The position is designed to study spatio-temporal mechanisms that control the assembly and signal transduction of the TCR and PD1 pathways at the T cell plasma membrane.   Our group is interested in the regulation of lymphocyte activity and functions during cancer and autoimmunity. Current research is focused on the activating T cell receptor (TCR) and inhibitory PD1 pathways in T cells. We apply multidisciplinary approaches that combine cutting-edge fluorescence microscopy with biophysics, biochemistry and molecular biology to elucidate how protein conformations, modifications and assembly at the plasma membrane control signal transduction. Specifically, we have discovered that the T cell signaling pathways are segregated into distinct plasma membrane nanodomains that concatenate upon T cell stimulation. We are studying how the signaling pathways utilize nanodomain distributions and dynamics, and how signals are exchanged between them. We aim to identify and modulate spatio-temporal mechanisms that are specific to signaling proteins and/or pathways. Our goal is to determine the potential of these mechanisms as future drug targets for immunotherapies.   To Apply: Please submit (1) a letter of motivation including a description of past research accomplishments and future research interests/goals (not more than two pages), (2) curriculum vitae (CV) with publication list and (3) at least three contact details for referees. Please, send your application in a single pdf file to: lillemeier@bio.uni-freiburg.de

DBI-INFRA is looking for a new colleague with a strong bioimage analysis background, problem-solving mindset, drive to learn and collaborate in multidisciplinary environments, and ideally with experience in service provision. The candidate profile Required

• Experience with common bioimage analysis software (such as ImageJ, QuPath and Napari) or with image processing and data science libraries (such as scikit-image, Pytorch, Dask …)
• Proficiency in image processing theory
• Service-oriented mindset, with a strong interest in training, user support and scientific outreach
• Strong programming experience in at least one high level programming language (e.g. Python)
• Strong problem-solving mindset and ability to collaborate in interdisciplinary environments
• Good organizational and communication skills

This position is limited until 31.3.2027, with the possibility of extension.

Junior Researcher – ImmunoHUB Project Institution: IBMC/i3S – Advanced Light Microscopy Platform, Porto, Portugal Project: Beyond ImmunoHUB – ERA Chair in Immunology Funding: European Union (Norte2030/FEDER) Contract Duration: 13 months, potentially extendable Application Period: August 14 – September 4, 2025 Apply at: IBMC Application Portal

🧪 Role & Responsibilities

• Develop and optimize image analysis pipelines for microscopy data
• Apply machine learning and deep learning to biological imaging
• Ensure reproducibility and quality control in data analysis
• Train and consult researchers on experimental design and image processing 🎓 Required Qualifications
• PhD in Engineering, Mathematics, Computer Science, Physics, Life Sciences, or related field
• Experience with biological image analysis (segmentation, tracking, registration)
• Proficiency in Python and statistical analysis
• Strong communication and collaboration skills
• Fluency in English 🌟 Desirable Skills
• Familiarity with ImageJ/Fiji, CellProfiler, QuPath, Napari
• Experience with ML/DL frameworks (U-Net, StarDist, Cellpose)
• Knowledge of advanced microscopy techniques and cloud-based platforms
• Background in interdisciplinary life sciences research

Full announcement at: https://dozer.i3s.up.pt/fileupload/downloadfile/viewpdfnewtab/60c5b648d0f7208f93fcab595d3b60ed

The University of Exeter’s Department of Biosciences (Streatham Campus) is inviting applications for a PhD studentship funded by the Leverhulme Trust to commence between October 2025 and January 2026. The studentship covers UK Home tuition fees plus an annual tax-free stipend of at least £20,780 for 4 years full-time. Based in an interdisciplinary lab, the student will use floating aquatic plants to unravel how plants tweak the wettability of their leaves, thereby paving the way for novel approaches to sustainable pest control. A supervisory team comprising a plant scientist, a cell biologist and a physicist, as well as two postdocs with expert experience in bioimaging, cuticular biochemistry, transcriptomics and bioinformatics, will provide bespoke training and advice at different stages of the project. Supported by this team, the student will (1) quantify the wettability of upper and lower leaf surfaces, (2) identify differences in cuticular composition, layering and surface texture, (3) disentangle the relative contributions of chemical composition and surface texture to wetting, and (4) investigate how plants can make surfaces with contrasting wetting properties within the same organ. This project offers a unique opportunity for a PhD student to acquire a very broad skill set of biochemical, biophysical, bioimaging and molecular techniques, combined with diverse data analysis and bioinformatics skills. The project would suit a student with a background in plant science, cell biology, molecular biology or biochemistry. Excellent oral and written communication skills and the ability to work in an interdisciplinary team are essential. An additional background in bioimaging, analytical chemistry or physics, as well as experience with practical lab work (e.g. from a previous Masters degree) are advantageous. Interested students are strongly encouraged to contact the lead supervisor, Dr Ulrike Bauer, to discuss the details of the project ahead of applying. The funding provided for this studentship cannot be used to recruit students who are classed as International for fees.

The University of Exeter’s Department of Biosciences (Streatham Campus) is inviting applications for a PhD studentship funded by the Leverhulme Trust to commence between October 2025 and January 2026. The studentship covers UK Home tuition fees plus an annual tax-free stipend of at least £20,780 for 4 years full-time. Based in an interdisciplinary lab, the student will use carnivorous pitcher plants to unravel how plants tweak the wettability of their leaves, thereby paving the way for novel approaches to sustainable pest control. The student will join a research group with a broad interest in plant biomechanics, ecology, development and evolution. Supported by this team, the student will investigate (1) the implications of different topographical features for surface wetting and water spreading, (2) the chemical composition of the cuticles covering wettable surfaces, and (3) the developmental and genetic underpinnings of surface formation. The project offers a unique opportunity to acquire a broad skill set of biochemical, biophysical, bioimaging and molecular techniques while working with a charismatic carnivorous plant system. It would suit a student with a background in plant science, cell biology, molecular biology or biochemistry. Excellent oral and written communication skills and the ability to work in an interdisciplinary team are essential. An additional background in physics or experience with practical lab work or bioimaging are advantageous. The studentship will be awarded on the basis of merit. Shortlisted candidates will be invited for an interview in late September 2025. The funding provided for this studentship cannot be used to recruit students who are classed as International for fees.

The serotonin (5-HT) system is essential for brain development and is closely linked to neurodevelopmental disorders such as anxiety and depression. While serotonergic axons reach most forebrain regions by birth, their maturation involves region- and time-specific innervation that extends into adolescence. Our lab has used whole-brain tissue clearing, light-sheet imaging, and machine learning to map the spatial and temporal dynamics of serotonin axon development. However, these methods lack the resolution needed to analyse axon branching and synapse formation. This project aims to establish a high-resolution imaging pipeline by incorporating expansion microscopy (ExM) into our existing workflow. The goal is to visualise serotonergic wiring at subcellular resolution across developmental stages, enabling analysis of how circuit assembly is altered when crucial wiring regulators are disrupted. This work will lay the foundation for linking abnormal serotonin wiring to the emergence of neurodevelopmental disorders. We are looking for a highly motivated individual who will thrive in a friendly and supportive group. Candidates must hold a PhD degree (or equivalent) due to be completed within 6 months in neuroscience, psychiatry or a related field. Basic biochemistry and molecular biology skillsets are required. We strongly encourage applications from candidates with advanced microscope training. Rodent working experience, especially mouse genetics training, is preferred.

To develop a dynamic, integrated view of biological systems in health and disease, the Chan Zuckerberg Institute for Advanced Biological Imaging (CZ Imaging Institute) aims to push forward the development and application of new imaging technologies over the next 10 to 15 years. CZ Imaging Institute researchers will collaboratively develop breakthrough biological imaging systems centered around grand challenges that push the boundaries of what we can see and measure to obtain deep insights into the architecture of complex biological systems at the molecular level. As an extension of the Chan Zuckerberg Initiative’s Imaging program, the CZ Imaging Institute (https://czii.org/) will create breakthrough technologies — hardware, software, biological probes, data, and platforms — that will be made available to the scientific community and adopted worldwide through a combination of direct access to the Institute, open sharing of advances, and commercial partnerships.

The Opportunity 

We are seeking a highly motivated and skilled Software Engineer to join our team in supporting the development of software tools, visualization frameworks, and data curation and management strategies for cryo-electron tomography (cryoET) and other imaging modalities. The ideal candidate will possess strong technical and communication skills, familiarity with large datasets and data deposition on public repositories, and experience developing and/or contributing to open-source software packages.

What You’ll Do

We envision this role as spanning multiple responsibilities depending on the background and interests of the candidate, including:

• Supporting the development of in-house software projects that visualize data performance,
• integrate new algorithms into the CryoET Data Portal for community use, and benchmark current
• pipelines
• Developing and implementing comprehensive data storage policies and guidelines
• Curating data for the CZII CryoET Data Portal by maintaining metadata standards and
• documentation, preparing datasets for repository ingestion, and ensuring data quality and
• accessibility
• Testing new algorithms released by other groups in the field to in-house data and integrating well-
• performing tools into in-house workflows
• Identifying and prototyping steps of the workflow suitable for AI integration

  What You’ll Bring

  Essential – ● Bachelor’s degree in Computer Science, Information Technology, or related field ● 3-5 years of professional data management experience ● Proficiency in Linux and Python scripting ● Exceptional organizational skills ● Strong analytical and problem-solving abilities ● Ability to develop and implement data management strategies ● Excellent communication skills Nice to have - ● Experience with high-performance computing clusters and/or AWS ● Database management skills ● Experience handling and processing massive datasets ● Familiarity with cloud storage solutions ● Sufficient knowledge of GPU types to recommend future hardware acquisition

  Compensation

  The Redwood City, CA base pay range for this role is $116,000.00 - $148,500.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

  Environment:

  We are an onsite work environment located in Redwood City, CA, enabling a collaborative and supportive culture. This position will be situated in a typical office setting, with some interaction with team members located in low-risk laboratories, shipping and receiving, and reception areas. What We Provide

• Resources to collaboratively develop breakthrough biological imaging systems that push the boundaries of what we can see and measure
• An environment where nothing is considered impossible, where bold and creative thinking are the norm, and where a collaborative culture allows teams of people from multiple disciplines to accomplish more than any single person can achieve alone
• Access to collaborators and resources at partner organizations in the CZ Biohub Network and beyond
• Competitive compensation and benefits commensurate with experience If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Benefits We offer a robust benefits program that enables the important work employees do everyday. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists.

The Opportunity

The position is focused on developing novel hardware technologies to extend the capabilities of cryogenic FIB-SEM to enable a deeper understanding of cell architecture and function at molecular resolutions. In this, the 3D cellular structure of unstained, vitrified cells is to be systematically imaged at the highest possible resolutions. The challenge is that contrast of non-lipid structures is very low in the SEM, and the research will focus on developing alternative contrast strategies using an in-tool AFM. This on-site position will be based in Redwood City, CA.

What You’ll Do:

• Develop improved methods and workflows for imaging and analyzing unstained biological samples within the FIB-SEM (with AFM)
• Explore novel approaches for successively imaging the surface of FIB-milled vitrified biological samples using the AFM or related scanning probe optical methods 
• Collaborate closely with platform and technical research teams at CZII
• Collaborate broadly with the scientific community
• Write papers and present findings at scientific conferences
• Mentor and train junior researchers in the lab
• Keep up-to-date with the latest research in the field and identify new areas of investigation.
• You will understand the challenges and opportunities for the Institute, and prioritize where to focus our efforts in biological research as well as how to best apply novel technology developments to provide the highest impact and results to the scientific community You have: 
• PhD in Chemistry, Physics, Engineering or related field
• A strong track record of research accomplishments in AFM imaging
• Excellent analytical skills 
• Ability to design and fabricate instrumentation
• Ability to work independently as well as part of a team
• Excellent written and verbal communication skills
• Outstanding attention to detail, accuracy, and procedures
• Must have the ability to multitask and work with technology developers in a highly collaborative environment

  Nice to have: 

• Experience with cryogenic imaging
• Python or other coding expertise
• FIB-SEM on biological samples
• Near-field optical imaging experience

  Compensation:

  The Redwood City, CA base pay range for this role is $108,000.00 - $148,500.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

I would like to share an exciting opportunity at Karolinska Institutet, where we are currently recruiting 20 Assistant Professors with a strong focus on scientific excellence. At the Department of Medicine, Huddinge (MedH), we are looking to recruit up to two Assistant Professors in the fields of molecular or translational medicine. We are seeking early-career researchers with a strong scientific drive and the ambition to grow in an international, collaborative environment. As part of MedH, new faculty members will benefit from:

• Strong academic mentorship and career support
• Access to state-of-the-art infrastructure and a modern preclinical animal facility
• Rich clinical cohorts and biobank resources
• A competitive salary and a generous startup package
• A vibrant research environment spanning stem cell biology, immunology, infectious diseases, hematology and cancer, gastroenterology and hepatology, cardiovascular research, nutrition, metabolism and diabetes, and aging
• A fantastic microscopy core facility! :) The position is open to international applicants and includes a generous funding package. Please help us spread the word! Application deadline: 2 September 2025 More information and application: Assistant Professor in molecular or translational medicine

The University of Wyoming Science Institute and the University of Wyoming Office of Research and Economic Development invites applications for the director of the new Center for Advanced Scientific Instrumentation (CASI) (https://www.uwyo.edu/science-initiative/casi) beginning in the Fall of 2025. Applicants with experience in quantitative imaging techniques from all fields of physical and life sciences are encouraged to apply. ESSENTIAL DUTIES AND RESPONSIBILITIES:

As an expert in light microscopy you will join a core facility team as a consultant for researchers at Novartis Basel. You will also play a key part in supporting scientific projects by advising users, coordinating resource sharing, and contributing to the maintenance and optimization of microscopy infrastructure.

The Bowman lab is seeking to recruit a postdoctoral fellow to develop novel instrumentation and methods for high-speed optical microscopy. We have developed nanosecond imaging techniques that enable new approaches for achieving fast, quantitative measurements of fluorescent biosensors. Using these approaches, we are building customized microscopes from the ground up to enable imaging of complex cellular signals in vivo and in 3D tissue environments. Our work is interdisciplinary by nature, and candidates may come from many different backgrounds including engineering, physics, bioengineering, and neuroscience. For this role we are seeking applicants with prior experience developing optical and/or electronic instrumentation and methods. For example, candidates may have experience building (1) Microscopes – e.g. fluorescence, nonlinear, super-resolution, or label-free techniques, (2) Laser, optical, or atomic physics experiments, (3) Instrument control systems, RF electronics, or image data analysis pipelines, or (4) Imaging and electrophysiology systems for in vivo measurements. We are committed to working across disciplinary boundaries and to providing a training environment with strong mentorship and career development opportunities. Candidates will have significant opportunities for creativity in defining project directions and will have the chance to participate in fruitful collaborations both within Salk and with external research groups.

The Euro-BioImaging Bio-Hub hosted by the European Molecular Biology Laboratory (EMBL) is looking for a highly motivated science professional and manager to support EC-funded projects, in particular IMAGINE, including technology validation by our Nodes and user project management, relevant engagement with the imaging community and outreach activities to researchers in the life sciences, as part of the operation of the European research infrastructure Euro-BioImaging ERIC (www.eurobioimaging.eu). Euro-BioImaging ERIC offers life scientists open access to imaging instruments, expertise, training opportunities, and data management services that they do not find at their home institutions or among their collaboration partners. All scientists, regardless of affiliation, area of expertise, or field of activity, can benefit from these pan-European open access services. Euro-BioImaging offers state-of-the-art imaging services through its internationally renowned facilities called Nodes. These Nodes are distributed across Euro-BioImaging’s 19 members. The management entity of Euro-BioImaging, the so-called Hub, is distributed across three sites: the legal seat is based in Finland, the Med-Hub in Italy, and the Bio-Hub is hosted by EMBL in Heidelberg, Germany. This post is for the Bio-Hub at EMBL. Your role  IMAGINE is an EC funded project coordinated by EMBL for developing and establishing “Next generation Imaging technologies to probe structure and function of biological specimen across scales in their natural context”.   The goal of this cross-disciplinary initiative is to develop next generation of scale-crossing imaging technologies needed to enable an integrated investigation of structure and function of biological systems, and to bring those technologies not only to highly specialized central facilities and standard laboratory models, but also out in the field, at Europe’s coastline and on the ocean. For achieving this goal, the IMAGINE consortium brings together leading European technology developing institutions, with leading industrial companies and the pan-European RIs in structural biology, bioimaging and marine biology. Integrating the expertise and domains of the individual project partners, the IMAGINE project focuses on developing and integrating four major microscopy technologies: X-ray imaging, cryo electron microscopy, cryo and dynamic super-resolution microscopy and large volume intravital light microscopy. It furthermore develops the AI-powered image analysis and data integration/sharing capabilities. The Euro-BioImaging Bio-Hub (EMBL) is coordinating the validation of the newly developed technologies, tools and workflows for service readiness in collaboration with Euro-BioImaging Nodes (WP7), setting up procedures for advanced training of Research Infrastructure staff on the developed technologies together with the project partner Instruct and EMBRC (WP10), and fostering Integration of the newly developed services in core facilities across European RIs (WP11).   The successful applicant will lead IMAGINE WP7 and WP11, and manage relevant aspects of the Euro-BioImaging operation, deliverable and milestones in the consortium, supporting Euro-BioImaging tasks related to project implementation through IMAGINE. Responsibilities include but are not limited to:

• Working closely with the IMAGINE project partners developing the new integrative technologies to achieve a seamless transition from technology development to validation
• Contribute to implementation of validation guidelines and processes for effective incorporation of new technologies into future Euro-BioImaging services in close collaboration with experts and the Euro-BioImaging Nodes
• Foster and monitor validation of developed Bioimaging technologies with selected use cases at Euro-BioImaging Nodes
• Support procedures and workflows (roadmap) for integrating the validated IMAGINE technologies into cross-RI services pipelines
• Promote the exchange of experience between the different RIs with the goal of seamless integration of new technologies for service
• Provide consultation, administrative and management support for recruiting and implementing cross-RI demonstrator user projects from academia or industry implementing the newly developed services and correlative pipelines – for validating the workflows interoperability
• Representing imaging community needs in the development of IMAGINE
• Support the delivery of trainings and organisation of workshops for Research Infrastructure staff on the newly developed imaging technologies
• Reporting on project progress and outcomes to the EC as funder
• Communication and outreach activities to advertise Euro-BioImaging’s service portfolio in national and international life sciences’ events
• Strategic support for the Euro-BioImaging Hub and Nodes in preparing for participation in future Horizon Europe consortia
• Outreach to other European Research Infrastructures in the life sciences, also for supporting advanced user projects with requests for common access The successful applicant will be integrated into the international Bio-Hub and Hub team, working closely together with colleagues that are professionals in the fields of imaging technologies, project management, administration, communication & outreach, image data analysis and science policy. They will support the Head of Operations and the Director of the Bio-Hub at EMBL. You have 
• PhD in the life sciences ideally followed by additional professional experience in academia or industry or equivalent experience (postdoctoral training, service provision in a core facility, science project management, etc.).
• Experience in advanced biological imaging technologies.
• Experience in scientific project management in a competitive research environment.
• Proven ability to effectively interact with multiple stakeholders on international and interdisciplinary level and the ability to move between the scientific and managerial level.
• Excellent organisational, management, prioritising, communication, and interpersonal skills.
• Passionate about improving research conditions for European scientists by providing services to the community with a high motivation to leave an impact at work.
• Excellent problem-solving skills and the ability to proactively identify promising solutions even when working under tight deadlines.
• Fluency in written and spoken English. We are looking for a motivated self-starter with an open attitude towards new responsibilities and tasks. The successful applicant will have an intrinsic motivation to deliver, be well structured, rigorous and able to work independently. We welcome a creative, problem-solving colleague, who enjoys working in an international interdisciplinary team within a highly collaborative atmosphere. You may also have
• Experience in user support in microscopy facilities.
• Experience in funding acquisition and reporting duties.
• Experience in communication, marketing and professional networking. Contract length: 2,5 years Salary: Grade 5 (monthly salary starting from 3.9k EUR after tax) + other paid benefits based on personal circumstances 

NES Fircroft is recruiting a Senior Research Scientist to join a leading agricultural company dedicated to enhancing global food security. This role is based at our client's site in Bracknell on a 24-month contract. As a Senior Research Scientist, you will be part of the microscopy team within the Bioscience function in Crop Protection. You will conduct research on various projects related to structural studies or phenotyping changes from active ingredients.

Key Responsibilities:

• Provide proactive scientific and technical support for microscopy requests/tasks by performing studies using fluorescence or electron microscopy.
• Demonstrate proficiency with microscopy techniques (fluorescence and electron-based).
• Execute operational priorities as agreed with the Science Leader.
• Interpret and analyse data, presenting conclusions in detailed reports and presentations.
• Implement HSE actions to ensure operations meet defined standards

Qualifications:

• A BSc or MSc (preferred) or PhD in a relevant field related to microscopy and bioimaging.
• At least 1-2 years of laboratory-based experience.
• Proven experience in imaging plant or insect materials using optical and electron microscopy.

For more information on the role please contact Jade Stirk at jade.stirk@nesfircroft.com

Postdoctoral Fellow - Biomolecular Condensates, Protein Dynamics & GI Disease Weill Cornell Medicine - Division of Gastroenterology and Hepatology

The Platt Lab in the Division of Gastroenterology and Hepatology at Weill Cornell Medicine invites applications for a postdoctoral research position in molecular and cellular biology. We investigate how changes in protein mobility and biomolecular condensates contribute to human disease, with a particular focus on gastrointestinal pathophysiology.

The successful candidate will lead projects using advanced imaging techniques, including fluorescence recovery after photobleaching (FRAP) and single-particle tracking (SPT), to uncover how environmental stressors disrupt biomolecular condensates and protein dynamics. Our goal is to reveal disease mechanisms and identify tractable therapeutic targets. We are a newly established and growing lab that values scientific rigor, creativity, and collaboration.

Responsibilities

• Design and execute independent experiments using advanced imaging and molecular biology techniques
• Analyze protein mobility using quantitative imaging and computational tools
• Contribute to manuscript and grant writing
• Present research findings at internal seminars and external conferences
• Collaborate across disciplines to explore emerging models of disease pathogenesis

Qualifications

• PhD, MD/PhD, or equivalent degree in molecular biology, biophysics, systems biology, or a related field
• Strong background in imaging, microscopy, and cell biology
• Experience with image analysis software (e.g., ImageJ/FIJI, MATLAB, Python)
• Interest or experience in biomolecular condensates, protein dynamics, and/or redox biology
• Demonstrated ability to publish high-quality scientific work
• Creative, collaborative, and motivated to uncover fundamental disease mechanisms

Application Instructions To apply, please send the following to Dr. Jesse Platt at jep4025@med.cornell.edu:

• A one-page cover letter describing your research background and interests
• CV with a list of publications
• Contact information for 2–3 references The position is available immediately and will remain open until filled. Salary range: $61,008 – $74,088, based on experience and in accordance with WCM’s minimum stipend policy. Weill Cornell Medicine is an equal opportunity employer and encourages applications from candidates of diverse backgrounds. Learn more about our work: https://www.linkedin.com/in/jesse-platt-md-phd-a3a42621/

The Neuron Signaling Lab at NUS is seeking a motivated and skilled Research Fellow to join our interdisciplinary neuroscience team. We use advanced optical imaging and behavioral analysis to uncover how molecular pathways shape brain function, aiming to bridge molecular and systems neuroscience.

Our core platforms include: § 3D & 4D confocal fluorescence microscopy § 1P & 2P fluorescence microendoscopy § Fiber photometry & optogenetics § Genetically encoded molecular tools We focus on behaviors such as reward learning, fear learning and motor learning, with strong interest in primary cilia and nuclear signaling in the brain.

Position Summary: We seek a candidate with strong expertise in microscopy and computational image analysis to: 1. Support and enhance ongoing imaging projects in the lab 2. Develop AI-powered pipelines for analysis of microendoscopic calcium imaging, confocal fluorescence microscopy, and behavioral videos 3. Lead cross-modality image registration applications 4. Launch new projects that leverage our optical expertise to probe brain function

Preferred Qualifications & Expertise: § PhD in neuroscience, bioengineering, computational biology, or related field § At least one strong first-author publication in microscopy and/or image analysis is required § Strong background in optical imaging principles and microscopy (e.g., confocal, 2P, STED, or light sheet) § Demonstrated experience in image processing, quantitative analysis, and biological interpretation § Proficiency in AI/machine learning tools for image segmentation, transformation, registration, or tracking § Solid mathematical foundation for image analysis (e.g., affine transformations, convolutional filters, matrix and morphological operations) § Programming skills in Python, MATLAB, and/or experience with ImageJ, Napari, Imaris, TensorFlow, or PyTorch § Familiarity with in vivo imaging, optogenetics or spatial transcriptomics methods is a plus § Strong interest in bridging biological questions with quantitative approaches § Excellent problem-solving, collaborative, and communication skills

Environment & Opportunities: Our lab is part of a highly multidisciplinary research environment, with close collaborations in biochemistry, neural computation, and genomics. The successful candidate will be embedded in a vibrant scientific community and have access to a full suite of optical and behavioral neuroscience platforms. In addition to technical capability, we are looking for an individual excited by our novel multi-scale approach to neurobiology and eager to tackle complex, integrative questions.

Yale School of Medicine https://medicine.yale.edu/fib-sem/ The FIB-SEM Collaboration Core (F-SCC) at Yale School of Medicine is seeking a Senior Staff Scientist to join our pioneering team at the forefront of volume electron microscopy. The F-SCC leverages cutting-edge enhanced Focused Ion Beam Scanning Electron Microscopy (eFIB-SEM) technology to achieve large-volume imaging at nanometer isotropic resolution.

Position Summary: Under the supervision of the F-SCC Director, the Senior Staff Scientist will manage the image acquisition pipeline. Responsibilities include:

• Performing X-ray-guided FIB-SEM sample preparation
• Conducting enhanced FIB-SEM image acquisition
• Carrying out image registration, alignment, segmentation, and data analysis The successful candidate will be expected to work independently, multitask effectively, and perform experiments using advanced laboratory techniques, including enhanced FIB-SEM and X-ray micro-computed tomography (micro-CT). Collaboration and close communication with the supervisor, collaborators, and core members are essential.

Qualifications:

• Strong expertise in electron microscopy and related imaging technologies preferred
• Ability to manage multiple projects simultaneously and work independently
• Excellent teamwork, communication, and organizational skills

Consideration: please submit an application and cover letter describing how your previous research accomplishments and scientific interests fit with the scope of the research via this link.

The successful candidate will be an integral part of a team whose aim is to discover the next generation genetic therapies for a wide range of indications. The position requires enthusiasm, passion, attention to detail, and a desire to create new medicines for patients.